Protein Modification Reagents
Medchemexpress LLC Mal-PEG2-oxyamine TFA | 00-00-0 | MFCD00209801 | 96.5% | C12H17F3N2O7 | 10MG
Mal-PEG2-oxyamine TFA is a PEG-based bifunctional linker supplied as the trifluoroacetic acid (TFA) salt for use in PROTAC synthesis and other bioconjugation applications. It combines a maleimide reactive group with an oxyamine functional handle, and a short PEG2 spacer to enhance solubility and flexibility.
- Bifunctional linker enabling thiol and carbonyl conjugation.
- Maleimide permits rapid, thiol-selective coupling under mild conditions.
- Oxyamine enables chemoselective oxime ligation to aldehydes and ketones.
- PEG2 spacer increases aqueous solubility and reduces steric hindrance.
- Provided as TFA salt to improve stability and handling.
- High purity suitable for research and synthetic workflows.
eMolecules 1807503-89-4 | Benzyl-PEG5-CH2CO2tBu | Broadpharm | MFCD28122960 | 398.496 | C21H34O7 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCc1ccccc1 | 1g | 254745489
Benzyl-PEG5-CH2CO2tBu | Broadpharm | 1807503-89-4 | MFCD28122960 | 398.496 | C21H34O7 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCc1ccccc1 | 1g | 254745489
Medchemexpress LLC BCN-endo-PEG4-NHS 25mg
BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN which allows for further synthesis of macrocyclic complexes In click chemistry endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts
Medchemexpress LLC TCO-PEG4-VC-PAB-MMAE | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 10 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) assembly and click-chemistry bioconjugation workflows. It combines a trans-cyclooctene (TCO) click handle, a PEG4-Val-Cit-PAB cleavable linker, and the cytotoxic payload MMAE to enable site-selective conjugation and intracellular release of the payload.
- Provides a trans-cyclooctene (TCO) handle for inverse electron-demand Diels-Alder reactions with tetrazines.
- Contains a PEG4-Val-Cit-PAB cleavable linker for enzymatic payload release.
- Conjugated to MMAE to supply a potent cytotoxic payload for ADC research.
- High purity (99.3%) suitable for research and bioconjugation workflows.
- Characterized by molecular weight 1522.91 and formula C78H127N11O19.
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG3-azide | 97.0% | 977.30 | C50H97N4O12P | 10 MG
DSPE-PEG3-azide is an azide-functionalized lipid-polyethylene glycol conjugate with a triethylene glycol spacer terminating in an azide. It is provided for research use as a click-chemistry reagent to introduce azide groups into lipid assemblies, enabling surface modification and bioconjugation of micelles and nanoparticle formulations. Certificate of analysis reports a molecular weight of 977.30 and purity of approximately 97% (HPLC).
- Azide-terminated PEG spacer enables copper-catalyzed or strain-promoted click reactions.
- Amphiphilic lipid-PEG structure facilitates incorporation into micelles and liposomes.
- High purity suitable for research bioconjugation and nanoparticle preparation.
- Available in small pack sizes for method development and scale-up.
- Stable under typical storage conditions when kept desiccated and cold.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 10 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker containing a terminal maleimide group for thiol conjugation. The construct includes a PEG4 spacer and a valine-citrulline-PAB protease-cleavable sequence to enable enzymatic payload release after internalization.
- Cleavable valine-citrulline-PAB sequence for enzyme-triggered release.
- Maleimide terminal for efficient thiol conjugation to antibodies.
- PEG4 spacer increases solubility and reduces steric hindrance.
- High supplied purity for consistent conjugation performance.
- Soluble in DMSO; recommended storage sealed and away from moisture.
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-NHS ester) | 2128735-29-3 | ≥96.0% | C41H46N4O14 | 50 MG
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Functionality: PEG-based PROTAC linker.
- Application: Used in the synthesis of PROTACs.
- Mechanism: Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- Research Use: For research use only; not sold to patients.
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.7% | C17H27BrN2O9 | 50 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 552715488
Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 552715488
eMolecules 557756-85-1 | Fmoc-N-amido-PEG4-acid | Combi-Blocks | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694
Fmoc-N-amido-PEG4-acid | Combi-Blocks | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 117553694
eMolecules 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051
Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 799175051
Medchemexpress LLC Dspe-peg-nhs | MFCD03098978 | 80.0% | 5,000 Da | 50 MG
DSPE-PEG-NHS, MW 5000, is a pegylated phospholipid bearing an N-hydroxysuccinimide (NHS) reactive ester at the PEG terminus. The reagent (average MW 5,000 Da) provides an amine-reactive linker for covalent attachment of ligands to liposomes and lipid nanoparticles, while the PEG chain imparts steric stabilization and reduced protein adsorption, making it useful for formulation and bioconjugation research.
- Provides an NHS ester for covalent coupling to primary amines.
- Imparts PEGylation for steric stabilization and reduced protein adsorption.
- Enables liposome and nanoparticle surface functionalization.
- Average molecular weight approximately 5,000 Da.
- Typical purity reported as 80.0%.
- Suitable for bioconjugation and targeted drug-delivery research.
eMolecules 811442-84-9 | t-Boc-N-amido-PEG4-amine | Broadpharm | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 500mg | 272383834
t-Boc-N-amido-PEG4-amine | Broadpharm | 811442-84-9 | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 500mg | 272383834
eMolecules 2665664-66-2 | Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane | Broadpharm549.537 | C24H31N5O10 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 627958508
Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane | Broadpharm | 2665664-66-2549.537 | C24H31N5O10 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 627958508
Medchemexpress LLC NH2-PEG8-acid | 100mg
NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]