Protein Modification Reagents
ABclonal Technology PEG3 Rabbit pAb
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5 exons and a common promoter and both genes are paternally expressed (PMID15203203). Alternative splicing events connect their shared 5 exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Sigma Aldrich Fine Chemicals Biosciences Pronase from Streptomyces griseus |
Pronase from Streptomyces griseus |
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 100 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Ligands target E3 ubiquitin ligase and target protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
STA PHARMACEUTICAL US LLC Fmoc-N-PEG7-acid | 5 g | CAS 1863885-74-8 | MDL MFCD26142985
Fmoc-N-PEG7-acid is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1863885-74-8
- MDL: MFCD26142985
- InChIKey: QTWMNLIXRWCJSM-UHFFFAOYSA-N
- Molecular Weight: 619.708
- Molecular Formula: C32H45NO11
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25-octaoxa-4-azaoctacosan-28-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)O
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2COOH | 25 g | CAS 437655-96-4 | MDL MFCD26142983
Fmoc-NH-PEG6-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-96-4
- MDL: MFCD26142983
- InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
- Molecular Weight: 561.628
- Molecular Formula: C29H39NO10
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
- SMILES: O=C(NCCOCCOCCOCCOCCOCCOCC(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2
Medchemexpress LLC M-PEG4-NH-DBCO | 2228857-36-9 | 95.0% | C28H34N2O6 | 100 MG
m-PEG4-NH-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have Azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in synthesis of PROTACs
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2COOH | 50 g | CAS 437655-96-4 | MDL MFCD26142983
Fmoc-NH-PEG6-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-96-4
- MDL: MFCD26142983
- InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
- Molecular Weight: 561.628
- Molecular Formula: C29H39NO10
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
- SMILES: O=C(NCCOCCOCCOCCOCCOCCOCC(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2
ABclonal Technology RIN2 Rabbit pAb
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | 99.0% | C28H39N3O12 | 100 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a cereblon ligand based on Pomalidomide and a 6-unit PEG linker, making it suitable for use in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Contains a 6-unit PEG linker
- Used in technology for targeted protein degradation
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.17% | C47H61N5O9S | 100 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have azide groups
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC DBCO-PEG9-amine | 2353409-99-9 | C39H57N3O11 | 50 MG
DBCO-PEG9-amine is a PEG-based PROTAC linker designed for use in PROTAC synthesis. This click chemistry reagent features a DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- PEG-based linker structure
- Molecular weight: 743.88
- Appearance: light yellow to yellow oil
- Recommended storage at -20°C, protected from light and under argon
- Soluble in DMSO up to 100 mg/mL
Medchemexpress LLC Bis-Mal-Lysine-PEG4-TFP ester | 1426164-53-5 | 98.0% | C37H45F4N5O13 | 25 MG
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules connect a ligand for an E3 ubiquitin ligase with a ligand for a target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system. It is intended for research use only. For optimal stability, store at 4°C, protected from light. When in solvent, store at -80°C for 6 months or -20°C for 1 month, also protected from light.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system for selective protein degradation
- Highly soluble in DMSO (100 mg/mL)
- Demonstrates good solubility in various in vivo protocols